Topoisomerase II inhibitors, which include mitoxantrone, have been linked to the event of secondary acute myeloid leukemia and myelosuppression.?? ?? ???????? ??????? ?????????? ??? ????? ?????? ?? ??? ??????? ?????? ?? ?????? ??? ?? ??????? ??????? ??? ????? ???????? ??????:Mutagenesis Mitoxantrone was clastogenic inside the in vivo rat bone marro

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